2410081-60-4
Chemical Structure
PHTPP-1304
- CAS No.: 2410081-60-4
- Formula:C51H50F6N4O7
- Molecular Weight:944.96
InChIKey: RFLBGKJLIDOOAA-RRHRGVEJSA-N
SMILES: O[C@H](CNCCOCCOCCOC1=CC=C(C2=C3N(C(C(F)(F)F)=CC(C(F)(F)F)=N3)N=C2C4=CC=CC=C4)C=C1)COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5
Biological Activity: PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC). PHTPP-1304 induces the degradation of estrogen receptor ERβ through the autophagy pathway, rather than ubiquitination (DC50 ≈ 2 nM, in HEK293T cells; < 100 nM in ACHN renal carcinoma and MCF-7 breast cancer cells). PHTPP-1304 can induce the self-oligomerization of p62. PHTPP-1304 can be used to study various cancers mediated by ERβ[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PHTPP-1304 | 99.96% | PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC). PHTPP-1304 induces the degradation of estrogen receptor ERβ through the autophagy pathway, rather than ubiquitination (DC50 ≈ 2 nM, in HEK293T cells; < 100 nM in ACHN renal carcinoma and MCF-7 breast cancer cells). PHTPP-1304 can induce the self-oligomerization of p62. PHTPP-1304 can be used to study various cancers mediated by ERβ. | ||||||||||||||||||||
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Keywords
