2417298-29-2
Chemical Structure
FC-116
- CAS No.: 2417298-29-2
- Formula:C21H20FNO4
- Molecular Weight:369.39
InChIKey: HGVNKQONHGKNOE-KPKJPENVSA-N
SMILES: COC1=C(OC)C(OC)=CC(C(/C(C)=C/C2=CNC3=C2C=CC(F)=C3)=O)=C1
Biological Activity: FC-11 is a tubulin inhibitor. FC-116 inhibits the proliferation of colorectal cancer (CRC) cells, with IC50 values of 4.52 nM for HCT116 cells and 18.69 nM for CT26 cells. FC-11 can induce ER stress to generate excess ROS, leading to mitochondrial damage, thereby promoting apoptosis in colorectal cancer (CRC) cells by targeting microtubules. FC-116 exerts potent anti-tumor effects in vivo. FC-11 can be used for the study of colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FC-116 | 98.04% | FC-11 is a tubulin inhibitor. FC-116 inhibits the proliferation of colorectal cancer (CRC) cells, with IC50 values of 4.52 nM for HCT116 cells and 18.69 nM for CT26 cells. FC-11 can induce ER stress to generate excess ROS, leading to mitochondrial damage, thereby promoting apoptosis in colorectal cancer (CRC) cells by targeting microtubules. FC-116 exerts potent anti-tumor effects in vivo. FC-11 can be used for the study of colorectal cancer. | ||||||||||||||||||||
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Keywords
