2540502-26-7
Chemical Structure
PRX-2904
- CAS No.: 2540502-26-7
- Formula:C16H12F6N6O2
- Molecular Weight:434.30
IUPAC Name: (S)-1-methyl-3-(trifluoromethyl)-N-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)-1,2,4-oxadiazol-5-yl)ethyl)-1H-pyrazole-5-carboxamide
InChIKey: SFSLHKNGLMRBTO-ZETCQYMHSA-N
SMILES: CN1C(C(N[C@@H](C)C2=NC(C3=CC(C(F)(F)F)=NC=C3)=NO2)=O)=CC(C(F)(F)F)=N1
Biological Activity: PRX-2904 is an orally effective and selective KNa1.1 (KCNT1/Slack/Slo2.2) inhibitor with an IC50 of 40 nM against human KNa1.1-WT. PRX-2904 reduces abnormal neuronal firing in KCNT1 gain-of-function (GoF) models by inhibiting KNa1.1 channel activity. PRX-2904 is useful for research on epilepsy associated with KCNT1 gain-of-function variants[1].
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PRX-2904 | PRX-2904 is an orally effective and selective KNa1.1 (KCNT1/Slack/Slo2.2) inhibitor with an IC50 of 40 nM against human KNa1.1-WT. PRX-2904 reduces abnormal neuronal firing in KCNT1 gain-of-function (GoF) models by inhibiting KNa1.1 channel activity. PRX-2904 is useful for research on epilepsy associated with KCNT1 gain-of-function variants. | |||||||||||||||||||||
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