2550398-08-6
2550398-08-6
Chemical Structure
Thalidomide-5-(PEG2-amine)
- CAS No.: 2550398-08-6
- Formula:C20H24N4O7
- Molecular Weight:432.43
IUPAC Name: N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxamide
InChIKey: JHPUXMJZJYXENI-UHFFFAOYSA-N
SMILES: NCCOCCOCCNC(C1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O
Biological Activity: Thalidomide-5-(PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility.
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Thalidomide-5-(PEG2-amine) | Thalidomide-5-(PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility. | |||||||||||||||||||||
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Keywords
