2653338-67-9
Chemical Structure
PROTAC EZH2 Degrader-23
- CAS No.: 2653338-67-9
- Formula:C55H68N8O7
- Molecular Weight:953.18
InChIKey: WFINBOKPKYVHJN-VBIMAARKSA-N
SMILES: CC[C@@H](N1C2=CC(C3=CN=C(C=C3)N4CCN(CC4)CCCCCCCCCCCOC5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C(C)=C1)C
Biological Activity: PROTAC EZH2 Degrader-23 (compound 8) is a PROTAC protein degrader targeting EZH2 with a target IC50 of 30.00 nM. PROTAC EZH2 Degrader-23 inhibits EZH2 methyltransferase activity via interaction with the EZH2 SET domain[1].
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PROTAC EZH2 Degrader-23 | PROTAC EZH2 Degrader-23 (compound 8) is a PROTAC protein degrader targeting EZH2 with a target IC50 of 30.00 nM. PROTAC EZH2 Degrader-23 inhibits EZH2 methyltransferase activity via interaction with the EZH2 SET domain. | |||||||||||||||||||||
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Keywords