2658488-68-5
2658488-68-5
Chemical Structure
FGFR-IN-11
- CAS No.: 2658488-68-5
- Formula:C28H29ClN4O4
- Molecular Weight:521.01
InChIKey: RJOWKASSFBQDER-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CC1)C2=CC3=C(OC4=CC=C(C(Cl)=C4)NC(NC5CC5)=O)C=CN=C3C=C2OC)C=C
Biological Activity: FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models[1].
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FGFR-IN-11 | FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models. | |||||||||||||||||||||
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References
Keywords
