2692692-00-3
2692692-00-3
Chemical Structure
(2R,3R)-Firazorexton
Synonym(s): (2R,3R)-TAK-994 free base
- CAS No.: 2692692-00-3
- Formula:C22H25F3N2O4S
- Molecular Weight:470.51
InChIKey: VOSAWOSMGPKQEQ-RTBURBONSA-N
SMILES: CC(C)(O)C(N(CC[C@H]1NS(C)(=O)=O)[C@@H]1CC2=C(C(C3=CC(F)=CC(F)=C3)=CC=C2)F)=O
Biological Activity: (2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms[1]..
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(2R,3R)-Firazorexton | 99.85% | (2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms.. | ||||||||||||||||||||
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References
- [1]. Ishikawa T, Hara H, Kawano A, Tohyama K, Kajita Y, Miyanohana Y, Koike T, Kimura H. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204. [Content Brief]
Keywords
