2704562-80-9
2704562-80-9
Chemical Structure
LRRK2-IN-10
- CAS No.: 2704562-80-9
- Formula:C20H15N5O
- Molecular Weight:341.37
InChIKey: WVOPQXJGCGZEPZ-SFHVURJKSA-N
SMILES: N#CC1=CC(CC2)=C(C=C1)[C@H]2NC3=CC4=C(C=C3)NN=C4C5=CON=C5
Biological Activity: LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].
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LRRK2-IN-10 | LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research. | |||||||||||||||||||||
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References
Keywords
