2747162-85-0
2747162-85-0
Chemical Structure
MCUF-651
- CAS No.: 2747162-85-0
- Formula:C17H22F2N4OS
- Molecular Weight:368.44
InChIKey: NOPAIELWJAFUCL-UHFFFAOYSA-N
SMILES: O=C(C1CN(CCC1)CCN(C)C)NC2=NC3=C(S2)C=C(F)C=C3F
Biological Activity: MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MCUF-651 | 99.85% | MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
