2750075-06-8
2750075-06-8
Chemical Structure
p53-MDM2-IN-5
- CAS No.: 2750075-06-8
- Formula:C33H37Cl4F2N5O6Pt
- Molecular Weight:974.57
InChIKey: KSGBFHRNVDTKCV-DSXGKOFBSA-J
SMILES: N#C[C@@]1(C2=C(C=C(C=C2)Cl)F)[C@@H](C3=C(C(Cl)=CC=C3)F)[C@@H](N[C@H]1CC(C)(C)C)C(NC4=C(C=C(C=C4)C([O-][Pt+4]([Cl-])([Cl-])([NH3])([NH3])[O-]C(C)=O)=O)OC)=O
Biological Activity: p53-MDM2-IN-5 (compound 5a) is a potent p53-MDM2 inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity[1].
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p53-MDM2-IN-5 | p53-MDM2-IN-5 (compound 5a) is a potent p53-MDM2 inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity. | |||||||||||||||||||||
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References
Keywords
