2756355-59-4
Chemical Structure
Glucocorticoid receptor antagonist-1
- CAS No.: 2756355-59-4
- Formula:C32H28FN3O
- Molecular Weight:489.58
InChIKey: ZRNGVDNOJWEGDW-UHFFFAOYSA-N
SMILES: O=C(N1CC(C2=CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C2C)(CC5=CC=CC=C5)CC1)C6=CC=CC=C6
Biological Activity: Glucocorticoid receptor antagonist-1 is an orally active glucocorticoid receptor (GR) antagonist with an IC50 of 27 nM and a Ki value of 32 nM, and it exhibits low agonist activity. Glucocorticoid receptor antagonist-1 shows moderate inhibitory effects on CYP2C9 and CYP2D6, and potent inhibitory effect on CYP2C8. Glucocorticoid receptor antagonist-1 prevents Olanzapine (HY-14541)-induced weight gain in female rats. Glucocorticoid receptor antagonist-1 can be used in studies related to weight gain[1].
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Glucocorticoid receptor antagonist-1 | Glucocorticoid receptor antagonist-1 is an orally active glucocorticoid receptor (GR) antagonist with an IC50 of 27 nM and a Ki value of 32 nM, and it exhibits low agonist activity. Glucocorticoid receptor antagonist-1 shows moderate inhibitory effects on CYP2C9 and CYP2D6, and potent inhibitory effect on CYP2C8. Glucocorticoid receptor antagonist-1 prevents Olanzapine (HY-14541)-induced weight gain in female rats. Glucocorticoid receptor antagonist-1 can be used in studies related to weight gain. | |||||||||||||||||||||
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Keywords
