2758802-10-5
2758802-10-5
Chemical Structure
HSD17B13-IN-17
- CAS No.: 2758802-10-5
- Formula:C20H16ClFN2O3S
- Molecular Weight:418.87
InChIKey: RPRXCKYWWGUQGM-UHFFFAOYSA-N
SMILES: OC1=C(Cl)C=C(C(NC2=C(C(NCCC3=C(F)C=CC=C3)=O)SC=C2)=O)C=C1
Biological Activity: HSD17B13-IN-17 (compound 9) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-17? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-17 | HSD17B13-IN-17 (compound 9) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-17? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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References
Keywords
