2758802-14-9
2758802-14-9
Chemical Structure
HSD17B13-IN-18
- CAS No.: 2758802-14-9
- Formula:C21H19ClN2O4S
- Molecular Weight:430.90
InChIKey: OWIMHUADAJLNKL-UHFFFAOYSA-N
SMILES: ClC1=CC(C(NC2=C(C(NCCC3=C(OC)C=CC=C3)=O)C=CS2)=O)=CC=C1O
Biological Activity: HSD17B13-IN-18 (compound 13) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-18? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-18 | HSD17B13-IN-18 (compound 13) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-18? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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References
Keywords
