2760246-90-8
Chemical Structure
PROTAC SMARCA2 degrader-22
- CAS No.: 2760246-90-8
- Formula:C44H51N9O5S
- Molecular Weight:818.00
InChIKey: PKJDUOKKYAXNLV-XLRCJOJLSA-N
SMILES: OC(C=CC=C1)=C1C2=CC(C(C=N3)=CC=C3N(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=CN=N2
Biological Activity: PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 < 250 nM[1].
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PROTAC SMARCA2 degrader-22 | PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 < 250 nM. | |||||||||||||||||||||
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Keywords