2762200-57-5
2762200-57-5
Chemical Structure
Trk-IN-8
- CAS No.: 2762200-57-5
- Formula:C18H16F2N6O2
- Molecular Weight:386.36
IUPAC Name: (31S,33S,63E,65E,8R)-15,66-difluoro-8-methyl-64,65-dihydro-2-oxa-4,7-diaza-6(3,5)-pyrazolo[1,5-a]pyrimidina-1(2,3)-pyridina-3(1,3)-cyclobutanacyclooctaphan-5-one
InChIKey: JXLZJPYLDDSEQF-IEBDPFPHSA-N
SMILES: O=C1N[C@H](C2)C[C@H]2OC3=NC=C(F)C=C3[C@@H](C)/N=C(N4)\C(F)=CN5C4=C1C=N5
Biological Activity: Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3)[1].
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Trk-IN-8 | Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3). | |||||||||||||||||||||
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