2793405-20-4
Chemical Structure
SOS1-IN-14
- CAS No.: 2793405-20-4
- Formula:C29H29F3N6O2
- Molecular Weight:550.57
IUPAC Name: 1-((S)-12-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-10-methyl-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1',2':4,5][1,4]oxazepino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile
InChIKey: UVNQICXVXBBWBT-AEFFLSMTSA-N
SMILES: N#CC1(C(N2C[C@]3([H])CCOC4=CC5=NC(C)=NC(N[C@@H](C6=CC=CC(C(F)F)=C6F)C)=C5C=C4N3CC2)=O)CC1
Biological Activity: SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SOS1-IN-14 | 99.60% | SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
