2851841-61-5
Chemical Structure
Menin-MLL inhibitor-22
- CAS No.: 2851841-61-5
- Formula:C29H39N7O3S
- Molecular Weight:565.73
IUPAC Name: N-(1-((1-(4-(cyclopropylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-6-(2-(dimethylamino)ethoxy)pyrido[3,2-d]pyrimidin-4-amine
InChIKey: MWXGAMJNJKYTPA-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N2CC(CN3CCC(NC4=NC=NC5=CC=C(N=C54)OCCN(C)C)CC3)C2)C=C1)(C6CC6)=O
Biological Activity: Menin-MLL inhibitor-22 (compound C20) is an orally active inhibitor of the interaction between menin and mixed lineage leukemia (MLL) (IC50=7 nM). Menin-MLL inhibitor-22 binds menin protein and inhibits cancer cell growth (MV4 cells, IC50=0.3 μM). Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome)[1].
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Menin-MLL inhibitor-22 | 99.85% | Menin-MLL inhibitor-22 (compound C20) is an orally active inhibitor of the interaction between menin and mixed lineage leukemia (MLL) (IC50=7 nM). Menin-MLL inhibitor-22 binds menin protein and inhibits cancer cell growth (MV4 cells, IC50=0.3 μM). Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome). | ||||||||||||||||||||
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Keywords
