2855085-25-3
Chemical Structure
MS8815
- CAS No.: 2855085-25-3
- Formula:C65H87N9O8S
- Molecular Weight:1154.51
IUPAC Name: 4,4-dihexyl-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-silolo[3,2-b:4,5-b']dithiophene
InChIKey: AOIZISCRIVNZJJ-XWJFFXCMSA-N
SMILES: CC(C=C(C)N1)=C(CNC(C2=C(C)C(N(CC)C3CCOCC3)=CC(C4=CC=C(CN5CCN(C(CCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)=O)CC5)C=C4)=C2)=O)C1=O
Biological Activity: MS8815 is a EZH2 PROTAC degrader, with a DC50 of 140 nM in MDA-MB-453 triple-negative breast cancer (TNBC) cells and an IC50 of 8.6 nM against human EZH2. MS8815 induces ubiquitin-proteasome system-mediated degradation of EZH2, reduces the levels of EED, SUZ12, FOXM1, H3K27me3 and global m6A, and increases the protein level of HMGCS2. MS8815 can be used in the research of breast cancer and prostate cancer[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MS8815 | 99.95% | MS8815 is a EZH2 PROTAC degrader, with a DC50 of 140 nM in MDA-MB-453 triple-negative breast cancer (TNBC) cells and an IC50 of 8.6 nM against human EZH2. MS8815 induces ubiquitin-proteasome system-mediated degradation of EZH2, reduces the levels of EED, SUZ12, FOXM1, H3K27me3 and global m6A, and increases the protein level of HMGCS2. MS8815 can be used in the research of breast cancer and prostate cancer. | ||||||||||||||||||||
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- [1]. Corbin J, et al. EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene. 2024 Aug;43(36):2722-2736. [Content Brief]
- [2]. Yi Y, et al. A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR. Nature communications. 2026 Mar 26;17(1):4421. [Content Brief]
- [3]. Yum C, et al. Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2. Oncogenesis. 2025 Jul 12;14(1):24. [Content Brief]
- [4]. Dale B, et al. Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS pharmacology & translational science. 2022 Jul 08;5(7):491-507. [Content Brief]
- [5]. Sun D, et al. Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation. Journal of medicinal chemistry. 2022 Nov 10;65(21):14276-14288. [Content Brief]
- [6]. Yi Y, et al. EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway. The Journal of clinical investigation. 2026 Jan 16;136(2):e195840. [Content Brief]
- [7]. Vogt KC, et al. Tumor microenvironment-targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors. Science advances. 2025 Dec 05;11(49):eadu2292. [Content Brief]
Keywords
