2865841-81-0
Chemical Structure
PD-1/PD-L1-IN-13
- CAS No.: 2865841-81-0
- Formula:C36H34ClF2N3O9
- Molecular Weight:726.12
IUPAC Name: 4-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylphenyl)difluoromethoxy)-2-((((3S,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)amino)methyl)phenoxy)methyl)picolinonitrile
InChIKey: TUOSAPKOJRLJAP-JZFXKNFZSA-N
SMILES: CC1=C(C=CC=C1C(F)(F)OC2=C(Cl)C=C(CN[C@@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(OCC4=CC(C#N)=NC=C4)=C2)C5=CC=C(OCCO6)C6=C5
Biological Activity: PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model[1].
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PD-1/PD-L1-IN-13 | 99.52% | PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model. | ||||||||||||||||||||
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Keywords
