2890819-31-3
Chemical Structure
Mps1-IN-5
- CAS No.: 2890819-31-3
- Formula:C24H25N9
- Molecular Weight:439.52
IUPAC Name: 4-(3-amino-1H-indazol-1-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
InChIKey: PSGLRMCIIGRRLV-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(N5N=C(C6=CC=CC=C65)N)=N3)C=CN4
Biological Activity: Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1].
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Mps1-IN-5 | Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage. | |||||||||||||||||||||
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Keywords
