2920698-73-1
2920698-73-1
Chemical Structure
HW161023
- CAS No.: 2920698-73-1
- Formula:C20H24F2N4O
- Molecular Weight:374.43
InChIKey: FTVQHQKWHIIDKY-FQEVSTJZSA-N
SMILES: CC(C)C[C@](C)(N)COC1=CC=C(C2=CC=NC(C(F)F)=C2)C3=NC=CN13
Biological Activity: HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model[1].
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HW161023 | HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model. | |||||||||||||||||||||
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References
Keywords
