2926610-43-5
Chemical Structure
TQ-3959
- CAS No.: 2926610-43-5
- Formula:C40H47N11O5
- Molecular Weight:761.87
IUPAC Name: 3-((4-(1-(1-(3-(2,6-dioxopiperidin-3-yl)benzo[d]isoxazol-6-yl)azetidin-3-yl)piperidin-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)pyrazine-2-carboxamide
InChIKey: MQYVYBLVYROROC-ZZTVPSNHSA-N
SMILES: NC(C1=C(NC2=CC=C(C3CCN(CC3)C4CN(C5=CC6=C(C=C5)C(C7CCC(NC7=O)=O)=NO6)C4)C=C2)N=C(N8C[C@H](N9CCN(C)C9=O)CCC8)C=N1)=O
Biological Activity: TQ-3959 is an orally active BTK PROTAC degrader with a DC50 of 0.4 nM. TQ-3959 selectively and efficiently degrades BTK by recruiting the CRBN E3 ubiquitin ligase and utilizing the ubiquitin-proteasome system. TQ-3959 can be applied in the research of B-cell malignancies and lymphomas[1].
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TQ-3959 | TQ-3959 is an orally active BTK PROTAC degrader with a DC50 of 0.4 nM. TQ-3959 selectively and efficiently degrades BTK by recruiting the CRBN E3 ubiquitin ligase and utilizing the ubiquitin-proteasome system. TQ-3959 can be applied in the research of B-cell malignancies and lymphomas. | |||||||||||||||||||||
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