2937327-83-6
2937327-83-6
Chemical Structure
pan-KRAS-IN-18
- CAS No.: 2937327-83-6
- Formula:C22H26N8OS
- Molecular Weight:450.56
InChIKey: ITTALXOYNGAVCQ-XMHCIUCPSA-N
SMILES: NC(S1)=C(C#N)C2=C1CCC[C@@]2(C3=NC(C4=NC(N5[C@@H](C)CNCCC5)=NC=C4)=NO3)C
Biological Activity: pan-KRAS-IN-18 is a panKRAS inhibitor that inhibits KRAS WT and KRAS G12V with IC50s of 29 and 9 nM, respectively. pan-KRAS-IN-18 exhibits antiproliferative activity in KRAS-mutant cell lines. pan-KRAS-IN-18 can be used for lung cancer research[1][2].
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pan-KRAS-IN-18 | 99.93% | pan-KRAS-IN-18 is a panKRAS inhibitor that inhibits KRAS WT and KRAS G12V with IC50s of 29 and 9 nM, respectively. pan-KRAS-IN-18 exhibits antiproliferative activity in KRAS-mutant cell lines. pan-KRAS-IN-18 can be used for lung cancer research. | ||||||||||||||||||||
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References
Keywords
