2941088-96-4
Chemical Structure
WH244
- CAS No.: 2941088-96-4
- Formula:C83H105ClF3N13O11S4
- Molecular Weight:1681.51
InChIKey: BSXCOLDAQWGIQN-ZNQYNWELSA-N
SMILES: CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CN4CCN(CC(N5CCN(C[C@]6(C)CCC(C7=CC=C(Cl)C=C7)=C(CN8CCN(C9=CC=C(C(NS(C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@@H](CSC%11=CC=CC=C%11)CCN%12C[C@@H]%13OC[C@H]%12C%13)C=C%10)(=O)=O)=O)C=C9)CC8)C6)CC5)=O)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
Biological Activity: WH244 is a BCL-xL and BCL-2 PROTAC degrader with DC50 values of 0.6 nM and 7.4 nM, and Kd values of 6.14 nM and 3.1 nM, respectively. WH244 kills cancer cells dependent on BCL-xL and BCL-2 for survival. WH244 is applicable to relevant research on leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WH244 | 99.82% | WH244 is a BCL-xL and BCL-2 PROTAC degrader with DC50 values of 0.6 nM and 7.4 nM, and Kd values of 6.14 nM and 3.1 nM, respectively. WH244 kills cancer cells dependent on BCL-xL and BCL-2 for survival. WH244 is applicable to relevant research on leukemia. | ||||||||||||||||||||
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Keywords
