2953016-30-1
2953016-30-1
Chemical Structure
HDM2004
- CAS No.: 2953016-30-1
- Formula:C28H35N7O
- Molecular Weight:485.62
InChIKey: CGQYYOAJNZWYHU-WOJBJXKFSA-N
SMILES: CCN(CC1)CCC1N(N=C2)C=C2C3=CNC4=C3N=C(C5=CC=C(N6C[C@@H](C)O[C@H](C)C6)C=C5)C=N4
Biological Activity: HDM2004 is a selective, orally active, blood-brain barrier-penetrant HPK1 inhibitor with an IC50 of 1.89 nM. HDM2004 exhibits anticancer activity against colon cancer. HDM2004 shows synergistic activity when combined with anti-PD-L1 in syngeneic mouse models. HDM2004 can be used for the research of colon cancer[1].
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HDM2004 | HDM2004 is a selective, orally active, blood-brain barrier-penetrant HPK1 inhibitor with an IC50 of 1.89 nM. HDM2004 exhibits anticancer activity against colon cancer. HDM2004 shows synergistic activity when combined with anti-PD-L1 in syngeneic mouse models. HDM2004 can be used for the research of colon cancer. | |||||||||||||||||||||
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References
Keywords
