2957914-60-0
2957914-60-0
Chemical Structure
Anticancer agent 135
- CAS No.: 2957914-60-0
- Formula:C23H21F3N4OS
- Molecular Weight:458.50
InChIKey: MIMPYGQNLHSBED-UHFFFAOYSA-N
SMILES: FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
Biological Activity: Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models[1].
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Anticancer agent 135 | Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models. | |||||||||||||||||||||
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References
Keywords
