2983011-81-8
Chemical Structure
LSD1-IN-19
- CAS No.: 2983011-81-8
- Formula:C33H42N6O2
- Molecular Weight:554.73
IUPAC Name: 7-(benzyloxy)-N4-(1-benzylpiperidin-4-yl)-N2-(3-(dimethylamino)propyl)-6-methoxyquinazoline-2,4-diamine
InChIKey: CLMKFAVBRRFUGX-UHFFFAOYSA-N
SMILES: COC1=CC2=C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)NCCCN(C)C)C=C1OCC5=CC=CC=C5
Biological Activity: LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively[1].
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LSD1-IN-19 | LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively. | |||||||||||||||||||||
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Keywords
