3002409-47-1
Chemical Structure
PRMT5-IN-50
- CAS No.: 3002409-47-1
- Formula:C26H23F3N6O
- Molecular Weight:492.50
InChIKey: JERPFLOXNGYZCZ-OAHLLOKOSA-N
SMILES: C[C@@H](N(C(C1=CC=C2N=C(C(C3CC3)=CC2=C1)N)=O)CC4=CC=C(C=N4)C(F)(F)F)C5=NC=CC=N5
Biological Activity: PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50s value of 1.0, 536 nM for arginine symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice[1].
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PRMT5-IN-50 | PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50s value of 1.0, 536 nM for arginine symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice. | |||||||||||||||||||||
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Keywords
