301177-43-5
301177-43-5
Chemical Structure
ESI-08
- CAS No.: 301177-43-5
- Formula:C20H23N3OS
- Molecular Weight:353.48
IUPAC Name: 4-cyclohexyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
InChIKey: LSHOSZQLVLPEGG-UHFFFAOYSA-N
SMILES: N#CC1=C(C2CCCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Biological Activity: ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
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ESI-08 | 98.74% | ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation. | ||||||||||||||||||||
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References
Keywords
