3017179-52-8
3017179-52-8
Chemical Structure
PROTAC EGFR degrader 19
- CAS No.: 3017179-52-8
- Formula:C57H65N11O6S2
- Molecular Weight:1064.33
InChIKey: NKSRWALSQOBEJH-NBXUQKPISA-N
SMILES: O=C1N(CC2=C1C=C(C=C2)C(C=C3)=CN=C3N4CCN(CC4)CC5CCN(CC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)C5)C(C9=CC=CC=C9)C(NC%10=NC=CS%10)=O
Biological Activity: PROTAC EGFR degrader 19 is a potent EGFR PROTAC degrader. PROTAC EGFR degrader 19 bridges EGFR and VHL E3 ligase, thereby promoting ubiquitination and degradation of EGFR, which in turn blocks oncogenic signaling pathways. PROTAC EGFR degrader 19 can be used for research on non-small cell lung cancer[1].
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PROTAC EGFR degrader 19 | PROTAC EGFR degrader 19 is a potent EGFR PROTAC degrader. PROTAC EGFR degrader 19 bridges EGFR and VHL E3 ligase, thereby promoting ubiquitination and degradation of EGFR, which in turn blocks oncogenic signaling pathways. PROTAC EGFR degrader 19 can be used for research on non-small cell lung cancer. | |||||||||||||||||||||
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