3017180-18-3
3017180-18-3
Chemical Structure
DDO-8958
- CAS No.: 3017180-18-3
- Formula:C22H22FN5O2
- Molecular Weight:407.44
InChIKey: JUMXBRHFDXULAH-UHFFFAOYSA-N
SMILES: FC1=C(C=C(C=C1C2=C3NC=NC3=NC=C2)OCC4COC4)C5=C(N(N=C5C)C)C
Biological Activity: DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity[1].
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DDO-8958 | DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity. | |||||||||||||||||||||
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References
Keywords
