3020690-76-7
3020690-76-7
Chemical Structure
HDM-IN-1
- CAS No.: 3020690-76-7
- Formula:C17H15N5O
- Molecular Weight:305.33
InChIKey: FSWCVBMKBCDAKC-UHFFFAOYSA-N
SMILES: COC(C=C1)=CN=C1N/N=C(C2=NC=CC=C2)\C3=NC=CC=C3
Biological Activity: HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model[1].
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HDM-IN-1 | HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model. | |||||||||||||||||||||
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References
Keywords
