3027146-73-9
Chemical Structure
KGDI-109
- CAS No.: 3027146-73-9
- Formula:C22H27N3O6
- Molecular Weight:429.47
InChIKey: MWESOOHAWLPMAY-PMACEKPBSA-N
SMILES: COC1=CC=C(C=C1)C[C@@H](C(OC(C)C)=O)NC([C@H](CC2=CC=C(C=C2)[N+]([O-])=O)N)=O
Biological Activity: KGDI-109 is an orally active and selective Porphyromonas gingivalis dipeptidyl peptidase 7 (PgDPP7) inhibitor with an IC50 of 53.8 µM and a Ki of 25.1 µM. KGDI-109 is also a selective antibacterial agent that suppresses Porphyromonas gingivalis growth, reduces oral Porphyromonas gingivalis levels, and suppresses alveolar bone resorption. KGDI-109 preserves gut microbial diversity. KGDI-109 can be used for the research of periodontitis[1].
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KGDI-109 | KGDI-109 is an orally active and selective Porphyromonas gingivalis dipeptidyl peptidase 7 (PgDPP7) inhibitor with an IC50 of 53.8 µM and a Ki of 25.1 µM. KGDI-109 is also a selective antibacterial agent that suppresses Porphyromonas gingivalis growth, reduces oral Porphyromonas gingivalis levels, and suppresses alveolar bone resorption. KGDI-109 preserves gut microbial diversity. KGDI-109 can be used for the research of periodontitis. | |||||||||||||||||||||
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Keywords
