3038172-12-9
Chemical Structure
Anticancer agent 221
- CAS No.: 3038172-12-9
- Formula:C17H9F4NO3
- Molecular Weight:351.25
InChIKey: BNTGFUSYADVLCI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(C=C1)C(C=C(C(F)(F)F)O2)=O)C3=CC=C(F)C=C3
Biological Activity: Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models[1].
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Anticancer agent 221 | Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models. | |||||||||||||||||||||
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Keywords
