3040082-19-4
Chemical Structure
AZ13824374
- CAS No.: 3040082-19-4
- Formula:C30H39FN8O2
- Molecular Weight:562.68
IUPAC Name: (1R,2R,5S)-11-(8-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one
InChIKey: NGXAMXNWIHBLBN-JIMJEQGWSA-N
SMILES: O=C1N[C@H](C(C)C)[C@H]2C3=CC=CC=C3C[C@@H]1N2C(C4=NN5C(C(NC6CCN(CC(C)(F)C)CC6)=C4)=NN=C5C)=O
Biological Activity: AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1].
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AZ13824374 | 99.22% | AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer. | ||||||||||||||||||||
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Keywords
