3041141-72-1
Chemical Structure
LSD1-IN-26
- CAS No.: 3041141-72-1
- Formula:C27H25Cl2F2N3O
- Molecular Weight:516.41
IUPAC Name: (4-(3,4-dichlorophenyl)piperazin-1-yl)(3-((((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)methyl)phenyl)methanone
InChIKey: QNHOPWFOAWAAJS-HFZDXXHNSA-N
SMILES: O=C(N1CCN(CC1)C2=CC(Cl)=C(C=C2)Cl)C3=CC=CC(CN[C@@H]4C[C@H]4C5=CC=C(C(F)=C5)F)=C3
Biological Activity: LSD1-IN-26 (compound 12u) is a potent LSD1 inhibitor, with an IC50 of 25.3 nM. LSD1-IN-26 also inhibits MAO-A (IC50=1234.57 nM) and MAO-B (IC50=3819.27 nM). LSD1-IN-26 significantly induces apoptosis in MGC-803 cells. LSD1-IN-26 can be used for gastric cancer research[1].
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LSD1-IN-26 | LSD1-IN-26 (compound 12u) is a potent LSD1 inhibitor, with an IC50 of 25.3 nM. LSD1-IN-26 also inhibits MAO-A (IC50=1234.57 nM) and MAO-B (IC50=3819.27 nM). LSD1-IN-26 significantly induces apoptosis in MGC-803 cells. LSD1-IN-26 can be used for gastric cancer research. | |||||||||||||||||||||
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Keywords
