3049218-28-9
3049218-28-9
Chemical Structure
BRD4/NAMPT-IN-1
- CAS No.: 3049218-28-9
- Formula:C30H30ClN7O2S
- Molecular Weight:588.12
InChIKey: XOCKWBJNBUYYAL-SZIFGRNDSA-N
SMILES: ClC(C=C1)=CC=C1C2=N[C@@H](CC(NCCCNC(/C=C/C3=CN=CC=C3)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5
Biological Activity: BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BRD4/NAMPT-IN-1 | 99.45% | BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects. | ||||||||||||||||||||
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References
Keywords
