3052796-86-5
Chemical Structure
ZG-2585
- CAS No.: 3052796-86-5
- Formula:C19H17Cl2N3O4
- Molecular Weight:422.26
InChIKey: AHDURXGXMGCLDJ-UHFFFAOYSA-N
SMILES: CC(N1C(C=CC2=C1C=CN2C3=C(C=C(C=C3Cl)C(NCC(O)=O)=O)Cl)=O)C
Biological Activity: ZG-2585 is an orally active and selective thyroid hormone receptor β (THRβ) agonist. ZG-2585 selectively activates THRβ over THRα, driving allosteric conformational changes and coactivator recruitment. ZG-2585 reduces body weight, hepatic steatosis and lipid accumulation in a Western diet-induced metabolic disorder model. ZG-2585 can be used for the research of metabolic disorders, including obesity, dyslipidemia and metabolic dysfunction-associated steatohepatitis[1].
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ZG-2585 | ZG-2585 is an orally active and selective thyroid hormone receptor β (THRβ) agonist. ZG-2585 selectively activates THRβ over THRα, driving allosteric conformational changes and coactivator recruitment. ZG-2585 reduces body weight, hepatic steatosis and lipid accumulation in a Western diet-induced metabolic disorder model. ZG-2585 can be used for the research of metabolic disorders, including obesity, dyslipidemia and metabolic dysfunction-associated steatohepatitis. | |||||||||||||||||||||
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Keywords
