3056235-77-6
Chemical Structure
Antitumor agent-226
- CAS No.: 3056235-77-6
- Formula:C25H21ClF2N4O5
- Molecular Weight:530.91
InChIKey: OXCIVKXXOWONKE-VZUCSPMQSA-N
SMILES: O=C1C(Cl)=CCCN1C(/C=C/C2=CC=C(OCC3=CN(C4=CC=C(OC(F)F)C=C4)N=N3)C(OC)=C2)=O
Biological Activity: Antitumor agent-226 is a DNMT3A inhibitor and epigenetic modulator. Antitumor agent-226 inhibits cell proliferation and migration by downregulating DNA Methyltransferase, reducing global DNA methylation, and modulating JNK, ERK1/2, and p38 phosphorylation through the MAPK pathway to induce mitochondria-dependent apoptosis, G2/M phase arrest, autophagy, and ROS production. Antitumor agent-226 can be used for research on prostate cancer[1].
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Antitumor agent-226 | Antitumor agent-226 is a DNMT3A inhibitor and epigenetic modulator. Antitumor agent-226 inhibits cell proliferation and migration by downregulating DNA Methyltransferase, reducing global DNA methylation, and modulating JNK, ERK1/2, and p38 phosphorylation through the MAPK pathway to induce mitochondria-dependent apoptosis, G2/M phase arrest, autophagy, and ROS production. Antitumor agent-226 can be used for research on prostate cancer. | |||||||||||||||||||||
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