3077842-16-8
3077842-16-8
Chemical Structure
Tubulin polymerization-IN-73
- CAS No.: 3077842-16-8
- Formula:C23H23N3O4
- Molecular Weight:405.45
InChIKey: HDNKVYHDQCTTLI-UHFFFAOYSA-N
SMILES: NC1=CC(C2=CC(C3=CC=C(C(OC)=C3OC)OC)=C4N=CNC4=C2)=CC=C1OC
Biological Activity: Tubulin polymerization-IN-73 (Compound 37) is an inhibitor for microtubule polymerization with an IC50 of 1.8 μM. Tubulin polymerization-IN-73 arrests the cell cycle at G2/M phase, induces apoptosis in A549 cell, inhibits the proliferation of A549 WT and A549/T resistant cell with IC50 of 0.023 μM and 0.057 μM. Tubulin polymerization-IN-73 exhibits antitumor efficacy in mouse model[1].
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Tubulin polymerization-IN-73 | Tubulin polymerization-IN-73 (Compound 37) is an inhibitor for microtubule polymerization with an IC50 of 1.8 μM. Tubulin polymerization-IN-73 arrests the cell cycle at G2/M phase, induces apoptosis in A549 cell, inhibits the proliferation of A549 WT and A549/T resistant cell with IC50 of 0.023 μM and 0.057 μM. Tubulin polymerization-IN-73 exhibits antitumor efficacy in mouse model. | |||||||||||||||||||||
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References
Keywords
