3081054-30-7
![Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p11896.gif "Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 Chemical Structure")
Chemical Structure
Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2
- CAS No.: 3081054-30-7
- Formula:C42H51BrN8O8
- Molecular Weight:875.81
InChIKey: VZGSGFDSFXBITA-JABDCJIOSA-N
SMILES: OC1=CC=C(C[C@H](N)C(N[C@@H](C(N[C@@H](CC2=CC=C(Br)C=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N4CCC[C@@H]4C(N)=O)=O)C5)=O)=O)=O)CCCCNC5=O)=O)C=C1
Biological Activity: Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 is a MOR-selective antagonist with a pA2 value of 9.9. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 blocks G protein- and β-arrestin2-mediated downstream signaling pathways of MOR. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 significantly delays the development of μ-opioid agonist-induced analgesic tolerance by blocking peripheral MOR. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 is applicable to studies related to opioid receptor function and analgesic tolerance[1].
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Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 | Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 is a MOR-selective antagonist with a pA2 value of 9.9. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 blocks G protein- and β-arrestin2-mediated downstream signaling pathways of MOR. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 significantly delays the development of μ-opioid agonist-induced analgesic tolerance by blocking peripheral MOR. Tyr-c[D-Lys-p-Br-Phe-Phe-Asp]-D-Pro-NH2 is applicable to studies related to opioid receptor function and analgesic tolerance. | |||||||||||||||||||||
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