3099026-16-8
Chemical Structure
PLAGL2-IN-1
- CAS No.: 3099026-16-8
- Formula:C30H35Cl2N5O4S
- Molecular Weight:632.60
InChIKey: ZEWRJLAZMVJNGM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C2C=CC=CC2=C1)(NC3=CC(C(N4CCN(C(C(Cl)Cl)=O)CC4)=O)=CC=C3N5CCN(C(C)C)CC5)=O
Biological Activity: PLAGL2-IN-1 is a inhibitor of pleiomorphic adenoma-like protein 2 (PLAGL2) with a Kd of 2.23 µM. PLAGL2-IN-1 suppresses PLAGL2 transcriptional activity, induces G0/G1 cell cycle arrest, and apoptosis, thereby inhibiting hepatocellular carcinoma (HCC) cell proliferation. PLAGL2-IN-1 disrupts extracellular matrix organization and suppresses the PI3K-AKT pathway by reducing AKT phosphorylation. PLAGL2-IN-1 inhibits tumor growth in an HCCLM3 xenograft mouse model. PLAGL2-IN-1 can be used for the research of HCC[1].
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PLAGL2-IN-1 | PLAGL2-IN-1 is a inhibitor of pleiomorphic adenoma-like protein 2 (PLAGL2) with a Kd of 2.23 µM. PLAGL2-IN-1 suppresses PLAGL2 transcriptional activity, induces G0/G1 cell cycle arrest, and apoptosis, thereby inhibiting hepatocellular carcinoma (HCC) cell proliferation. PLAGL2-IN-1 disrupts extracellular matrix organization and suppresses the PI3K-AKT pathway by reducing AKT phosphorylation. PLAGL2-IN-1 inhibits tumor growth in an HCCLM3 xenograft mouse model. PLAGL2-IN-1 can be used for the research of HCC. | |||||||||||||||||||||
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Keywords
