310456-65-6
310456-65-6
Chemical Structure
IMR-1
- CAS No.: 310456-65-6
- Formula:C15H15NO5S2
- Molecular Weight:353.41
IUPAC Name: ethyl (E)-2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate
InChIKey: QHPJWPQRZMBKTG-KPKJPENVSA-N
SMILES: O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
Biological Activity: IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
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IMR-1 | 98.95% | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth. | ||||||||||||||||||||
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References
Keywords
