3105892-11-0
3105892-11-0
Chemical Structure
EST1140
- CAS No.: 3105892-11-0
- Formula:C30H32N4O6S
- Molecular Weight:576.66
InChIKey: OYKRDWCKCLWMBJ-VWHGBBLNSA-N
SMILES: COC1=CC=C(C(/C=C/C(N[C@@H]2C[C@@H](NC(COC3=CC=C(C4=CSC(N5CCOCC5)=N4)C=C3)=O)C2)=O)=O)C=C1
Biological Activity: EST1140 is a covalent molecular glue degrader targeting RNF126 for AR/AR-V7, with DC50 values of 33 μM and 30 μM, respectively, in 22Rv1 cells. EST1140 covalently binds to the E3 ligase RNF126 to achieve targeted protein degradation. EST1140 can be used in the research of androgen-independent prostate cancer[1].
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EST1140 | EST1140 is a covalent molecular glue degrader targeting RNF126 for AR/AR-V7, with DC50 values of 33 μM and 30 μM, respectively, in 22Rv1 cells. EST1140 covalently binds to the E3 ligase RNF126 to achieve targeted protein degradation. EST1140 can be used in the research of androgen-independent prostate cancer. | |||||||||||||||||||||
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