3110809-62-3
3110809-62-3
Chemical Structure
FAK-IN-32
- CAS No.: 3110809-62-3
- Formula:C24H34ClFN6O3S
- Molecular Weight:541.08
InChIKey: PUTHYDPRTZJMPI-UHFFFAOYSA-N
SMILES: OC1CCN(C2=CC=C(NC3=NC=C(Cl)C(NCC4CN(S(=O)(C(C)C)=O)CCC4)=N3)C=C2F)CC1
Biological Activity: FAK-IN-32 is an orally active, selective and highly potent FAK inhibitor (IC50 = 10.87 nM). FAK-IN-32 can induce cell cycle arrest at the G2/M phase, inhibit FAK-AKT signaling pathway activity, and promote apoptosis to some extent. FAK-IN-32 can be used for research on KRAS-mutant colorectal cancer[1].
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FAK-IN-32 | FAK-IN-32 is an orally active, selective and highly potent FAK inhibitor (IC50 = 10.87 nM). FAK-IN-32 can induce cell cycle arrest at the G2/M phase, inhibit FAK-AKT signaling pathway activity, and promote apoptosis to some extent. FAK-IN-32 can be used for research on KRAS-mutant colorectal cancer. | |||||||||||||||||||||
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References
Keywords
