3115940-07-0
Chemical Structure
Anticancer agent 304
- CAS No.: 3115940-07-0
- Formula:C42H46O8
- Molecular Weight:678.81
InChIKey: HBADSHKGLZXKRK-MOFXPXSSSA-N
SMILES: C[C@@]12C3=C([C@@](O)(CC[C@]4([H])[C@]3([H])OC(C4=C)=O)C)[C@@](C[C@@H]2C(C5=CC=C(C=C5)C([C@@H]6[C@@]7(C8=C([C@@](O)(CC[C@]9([H])[C@]8([H])OC(C9=C)=O)C)[C@](C7)([H])C6)C)=O)=O)([H])C1
Biological Activity: Anticancer agent 304 is an anticancer agent. Anticancer agent 304 binds to CDC45 with a Kd value of 83.0 μM. Anticancer agent 304 arrests the cell cycle of liver cancer cells at the G2/M phase, induces Apoptosis by upregulating C-PARP-1 and downregulating PARP-1 and BCL-2, and inhibits the migration, invasion and proliferation of liver cancer cells. Anticancer agent 304 suppresses tumor growth in animal models of hepatocellular carcinoma. Anticancer agent 304 is applicable to research related to liver cancer[1].
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Anticancer agent 304 | Anticancer agent 304 is an anticancer agent. Anticancer agent 304 binds to CDC45 with a Kd value of 83.0 μM. Anticancer agent 304 arrests the cell cycle of liver cancer cells at the G2/M phase, induces Apoptosis by upregulating C-PARP-1 and downregulating PARP-1 and BCL-2, and inhibits the migration, invasion and proliferation of liver cancer cells. Anticancer agent 304 suppresses tumor growth in animal models of hepatocellular carcinoma. Anticancer agent 304 is applicable to research related to liver cancer. | |||||||||||||||||||||
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Keywords
