3115940-40-1
Chemical Structure
PROTAC BRD4 Degrader-49
- CAS No.: 3115940-40-1
- Formula:C53H67N9O6S2
- Molecular Weight:990.29
InChIKey: YABHYBSKVQYRGI-SVRJHHFNSA-N
SMILES: CC1=C(SC2=C1C(C3=CC=C(C=C3)OCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@]([H])(C(N[C@@H](CCCCCCN5)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C4)=O)=O)=N[C@]([H])(C8=NN=C(N28)C)CC5=O)C
Biological Activity: BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer[1].
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PROTAC BRD4 Degrader-49 | BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer. | |||||||||||||||||||||
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Keywords
