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Cat. No.: HY-185854

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PROTAC BRD4 Degrader-49

BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer.
(Pink: BRD4 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3115940-40-1
Formula: C₅₃H₆₇N₉O₆S₂
Molecular Weight:990.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BRD4 Degrader-49 Chemical Structure

CAS No.: 3115940-40-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer^[1]. (Pink: BRD4 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker).

IC₅₀ & Target^[1]

BRD4

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

BRD4 degrader-8 (compound 12) (10 nM; 24 h) induces 81% degradation of BRD4 protein in PC-3 cells when administered at 10 nM for 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC-3 human prostate cancer cells
Concentration:

10 nM
Incubation Time:

24 h
Result:

Reduced BRD4 protein level by 81%.

Chemical Information

CAS No. 3115940-40-1
Molecular Weight 990.29
Formula C₅₃H₆₇N₉O₆S₂
SMILES

CC1=C(SC2=C1C(C3=CC=C(C=C3)OCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@]([H])(C(N[C@@H](CCCCCCN5)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C4)=O)=O)=N[C@]([H])(C8=NN=C(N28)C)CC5=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ding Ke, et al. Annular BRD4 protein degradation agent and application thereof. CN120965801A. 2025-11-18.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC BRD4 Degrader-49

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BRD4 Degrader-49 Related Classifications

HY-185854 Related Classifications