312928-72-6
Chemical Structure
CRTh2 antagonist 3
- CAS No.: 312928-72-6
- Formula:C19H20N2O3S
- Molecular Weight:356.44
IUPAC Name: 2-(2-((2-(2,6-dimethylphenoxy)ethyl)thio)-1H-benzo[d]imidazol-1-yl)acetic acid
InChIKey: ZAHFRMHMWCBLOL-UHFFFAOYSA-N
SMILES: O=C(O)CN1C2=CC=CC=C2N=C1SCCOC3=C(C)C=CC=C3C
Biological Activity: CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist[1]. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation[2].
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CRTh2 antagonist 3 | CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation. | |||||||||||||||||||||
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Keywords
