314267-57-7
314267-57-7
Chemical Structure
JNJ 17029259
- CAS No.: 314267-57-7
- Formula:C26H30N6O
- Molecular Weight:442.56
IUPAC Name: 4-(4-(2-aminopropan-2-yl)phenyl)-2-((4-(2-morpholinoethyl)phenyl)amino)pyrimidine-5-carbonitrile
InChIKey: MROGTPNQSHMKIG-UHFFFAOYSA-N
SMILES: CC(C)(N)C(C=C1)=CC=C1C2=NC(NC3=CC=C(CCN4CCOCC4)C=C3)=NC=C2C#N
Biological Activity: JNJ 17029259 is an orally active and selective VEGF-R2 kinase inhibitor. JNJ 17029259 inhibits VEGF-mediated signal transduction. JNJ 17029259 has anti-angiogenic activity[1][2].
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JNJ 17029259 | JNJ 17029259 is an orally active and selective VEGF-R2 kinase inhibitor. JNJ 17029259 inhibits VEGF-mediated signal transduction. JNJ 17029259 has anti-angiogenic activity. | |||||||||||||||||||||
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References
- [1]. Mohammed S. I. Makki, et al. Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors. Journal of Chemistry. 2014. Article ID 430573.
- [2]. Reuman M, et al. Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile. J Org Chem. 2008 Feb 1;73(3):1121-3. [Content Brief]
Keywords
